Dr Ashley Buckle
Associate Professor
Ashley Buckle is Chief Technology Officer and Co-Founder of a Stealth Biotech in San Diego. Previously he was VP, Head of Protein Engineering and Structural Biology at Replay, a genomic medicine/synbio biotech based in San Diego.
He has more than three decades of expertise in structural biology and protein engineering, and has published more than 155 papers. He is named author on 10 patents, encompassing: minichaperone refolding, hypo-immune iPS cells, development of activators of GAD65 as therapeutic agents in anxiety disorders, engineered antibodies, stabilised anti-inflammatory protein biologics, and highly stable monobodies. He has determined high resolution X-ray crystallographic structures of over 90 proteins, including several ‘firsts’ of medically important proteins; the autoantigen GAD65, Membrane Attack Complex / Perforin (MACPF)-like protein, the bacteriophage lysin PlyC, and T Cell receptor-MHC complex. Ashley performed his PhD studies at Cambridge University and the MRC Centre for Protein Engineering, in the group of Sir Alan Fersht, a founder and pioneer of protein engineering.
Ashley founded PTNG Consulting and Biovidera (now Biovidera Scientific Studios) in 2020 and handed over the reins to Simona in 2023. He now supports the team by identifying the most experienced protein engineers from his extensive academic and industry network that join the PTNG team permanently or to support specific projects only.
